Entries by andreashorn

Lead-DBS updates in 2018

Three months into 2018, there have been several studies that used Lead-DBS to answer very interesting questions briefly summarized below. 1. Siobhan Ewert and Todd Herrington could recently show that automated segmentations of the STN and GPi performed with Lead-DBS are nearly as precise as manual expert segmentations of the same structures in both a high-definition MRI […]

New PNAS Study on Lesion induced criminal behavior

We just published a new study spearheaded by R. Ryan Darby that used the Lesion Network Mapping approach developed by Michael Fox to analyse lesion induced criminal behavior. The study has been featured on multiple news outlets such as WSFA, Der Spiegel, The Independent and El País. Findings show that lesions leading to criminal behavior are connected […]

Explaining TMS treatment response in depression by means of functional connectivity

In a new BPS study (Prospective Validation That Subgenual Connectivity Predicts …) spearheaded by Anne Weigand and led by Michael D Fox, we were able to explain TMS treatment response by functional connectivity between the stimulation site in the left dorsolateral prefrontal cortex and the subgenual cingulate cortex. Specifically, strength of anticorrelations between DLPFC and subgenual were predictive […]

Electrophysiological Atlas of GPi Activity (Neumann 2017) included in Lead-DBS v2.0.0.6

Inside a new version of Lead-DBS (v2.0.0.6) released yesterday, we included the pallidal theta activity sweet spot defined in A localized pallidal physiomarker in cervical dystonia as well as optimal stimulation targets defined in Thomas Schönecker‘s Article Postoperative MRI localisation of electrodes and clinical ef… and Philip Starr’s Article Microelectrode-guided implantation of deep brain stimulators….  Since all three spots fall into a very […]

New SEM study out: “Relating pallidal theta activity to dystonic symptoms and anatomy of the GPi”

In a new study (A localized pallidal physiomarker in cervical dystonia) led by Wolf-Julian Neumann with Siobhan Ewert, Julius Huebl, Christof Brücke, Gerd-Helge Schneider and Andrea A Kühn, we were able to relate pallidal theta power to dystonic symptom severity for the first time. Furthermore, using the “Subcortical Electrophysiology Mapping (SEM)” approach developed as part of Lead-DBS (implemented inside the “Lead Group” module), […]

VTA-model support for segmented Leads

Till Dembek created a segmented Lead Mesh that allows us to run our FEM-calculations (see Connectivity Predicts deep brain stimulation outcome in Park…; model implemented based on SimBio with great help from Johannes Vorwerk) to create VTAs for these electrodes.

Lead-DBS 2.0 out now

We are proud to release Lead-DBS 2.0 to the community – an open source tool to localize Deep Brain Stimulation (DBS) electrodes in the human brain. A detailed description of all major new features is available here [http://www.lead-dbs.org/?p=3174], but in a nutshell they are: DISTAL atlas: A detailed brain atlas of the human subcortex based on histology […]

DISTAL Atlas methods summary, data out soon

Summary of novel subcortical atlas that is “made for Lead-DBS”, based on multispectral high-resolution MNI template, histology and structural connectivity (Ewert et al., 2017) here: http://www.lead-dbs.org/?page_id=2911 Dataset out soon, original publication here:http://www.sciencedirect.com/science/journal/aip/10538119?sdc=1

Major update of Lead-DBS out (v.1.6.5)

Summary here http://us8.campaign-archive2.com/?u=a5b93846a3a2a714edbcce8ef&id=7038e497df – Drag’n’Drop support – Improved ANTs presets – New Check Normalization viewer – New NIfTI image classifier – New atlases (PPN Alho 2017 atlas Magnetic resonance diffusion tensor imaging for the peduncul…, cerebellar parcellations)