Entries by andreashorn

Lead-DBS on the cover of Annals of Neurology

We’re really excited that the current cover of AoN was made with Lead-DBS. It shows pallidal and thalamic electrodes simultaneously implanted in a patient suffering from Tourette’s Syndrom and the picture is part of an electrophysiological Berlin-Hannover study spearheaded by Wolf-Julian Neumann and led by Andrea Kühn. It is the sixth coverart made with Lead-DBS […]

Important methodological updates for Lead-DBS

We are thrilled that the Lead-DBS v2 methodological paper is out in NeuroImage. [An unpaywalled preprint can be found here]. Lead-DBS was developed since 2012 and the first methods paper published in 2014. Since then, nearly everything has changed – and this led us to writing up the aforementioned updated methods paper. In the manuscript, […]

Brain Sciences Special Issue “Modulatory Effects of Deep Brain Stimulation on Distributed Brain Networks”

I am editing a special issue in the #openaccess journal Brain Sciences about “Modulatory Effects of Deep Brain Stimulation on Distributed Brain Networks“. In case you are working on topics that combine brain stimulation with connectomics, would like to write a review or short report in that domain, please consider submitting to this issue – deadline is […]

Lead-DBS updates in 2018

Three months into 2018, there have been several studies that used Lead-DBS to answer very interesting questions briefly summarized below. 1. Siobhan Ewert and Todd Herrington could recently show that automated segmentations of the STN and GPi performed with Lead-DBS are nearly as precise as manual expert segmentations of the same structures in both a high-definition MRI […]

New PNAS Study on Lesion induced criminal behavior

We just published a new study spearheaded by R. Ryan Darby that used the Lesion Network Mapping approach developed by Michael Fox to analyse lesion induced criminal behavior. The study has been featured on multiple news outlets such as WSFA, Der Spiegel, The Independent and El País. Findings show that lesions leading to criminal behavior are connected […]

Explaining TMS treatment response in depression by means of functional connectivity

In a new BPS study (Prospective Validation That Subgenual Connectivity Predicts …) spearheaded by Anne Weigand and led by Michael D Fox, we were able to explain TMS treatment response by functional connectivity between the stimulation site in the left dorsolateral prefrontal cortex and the subgenual cingulate cortex. Specifically, strength of anticorrelations between DLPFC and subgenual were predictive […]

Electrophysiological Atlas of GPi Activity (Neumann 2017) included in Lead-DBS v2.0.0.6

Inside a new version of Lead-DBS (v2.0.0.6) released yesterday, we included the pallidal theta activity sweet spot defined in A localized pallidal physiomarker in cervical dystonia as well as optimal stimulation targets defined in Thomas Schönecker‘s Article Postoperative MRI localisation of electrodes and clinical ef… and Philip Starr’s Article Microelectrode-guided implantation of deep brain stimulators….  Since all three spots fall into a very […]

New SEM study out: “Relating pallidal theta activity to dystonic symptoms and anatomy of the GPi”

In a new study (A localized pallidal physiomarker in cervical dystonia) led by Wolf-Julian Neumann with Siobhan Ewert, Julius Huebl, Christof Brücke, Gerd-Helge Schneider and Andrea A Kühn, we were able to relate pallidal theta power to dystonic symptom severity for the first time. Furthermore, using the “Subcortical Electrophysiology Mapping (SEM)” approach developed as part of Lead-DBS (implemented inside the “Lead Group” module), […]